Closed-Loop Autonomous Anesthesia Delivery Systems
#1Multiple generations of closed-loop anesthesia delivery systems have now cleared the proof-of-concept threshold in human clinical trials. SEDASYS (J&J, FDA-cleared 2013, withdrawn 2016 under ASA pressure) demonstrated that a closed-loop propofol system could safely perform procedural sedation without a physician present. McSleepy (McGill University, Hemmerling et al.) demonstrated fully autonomous induction, maintenance, and emergence using multi-drug closed-loop control in human subjects. Current-generation BIS-guided TCI platforms (B. Braun, Fresenius Kabi) are in clinical deployment with increasingly sophisticated feedback algorithms. Next-generation systems under development integrate EEG spectral analysis, hemodynamic closed-loop, and neuromuscular blockade management into unified autonomous platforms — with regulatory submissions to FDA and CE mark anticipated in the 2026–2029 window.